基因解密，预防耳聋的药物进入实验阶段

医学和听力学科普

噪声性耳聋基因解密，可能使得预防耳聋的药物成为可能！即从事噪声环境工作之前先服预防药物，或者在刚刚参加噪声环境工作之后服用。

发明者来自UCSF美国加州大学旧金山分校，该校的老师在年曾经帮助我完成了我自己的研究生毕业设计MACC!真是一千个赞。

Tmtc4蛋白的缺失导致了内耳毛细胞死亡。预防的药物是ISRIB(forIntegratedStressResponseInhibitor，整合应激反应抑制剂）

NewGeneDiscoveryCouldLeadtoHearingLossPreventionDrugNovember9,

AccordingtoarecentreportinanOctoberissueofTheJournalofClinicalInvestigation,ateamofUCSanFranciscoresearchershavediscoveredagenethatplaysanessentialroleinnoise-induceddeafness.

Byadministeringanexperimentalchemical—identifiedinaseparateUCSFlabin—thatactsonthepathwaylinkingthisgenetohearingloss,theresearchersfoundtheycouldpreventnoise-induceddeafnessinmice.Further,theresearcherssurmiseasimilardrugtotheoneusedintheirstudymightonedaybeusedasahearing-protectionregimen(oto-protectiveagent)beforeworkinginanoisyenvironment,usingloudtoolsorattendingaraucousconcert.

Theresearchteamisalsoexaminingwhethertheotoprotectiveagentcouldbetakenshortlyafterexposuretoloudnoisetoprotecthearing.

LeadresearcherElliottSherr,professorofneurologyandofpediatricsatUCSFandcolleagueswereinterestedinagenecalledTmtc4foritspotentialroleinbraindevelopment.Whentheteamdeletedthegeneinmouseembryos,theyweresurprisedtodiscoverthatthemicebecamealmost







































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